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This model is operationally feasible only where the protocol's safety and efficacy requirements can be entirely satisfied through validated remote instruments: ePRO platforms, wearable biosensors, home nursing procedures, telemedicine investigator visits, and direct-to-patient supply chain logistics

Mix in the wrong elements certain medications, unsafe dosing, or ignoring your own health context and you risk snuffing out the flame entirely

Statistical analysis The results are expressed as mean SEM

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